Let Expedia help you arrange your flight to Winston-Salem, NC (INT-Smith Reynolds) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay special. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Wilkesboro offers. Wilkesboro has some interesting things to see and do including W Kerr Scott Reservoir and Wilkes Heritage Museum, so you might want to take in the local sights during your visit.