You can pick up a cheap car rental near Grand Lake O the Cherokees, but several things will determine the price of your ride. Among these are your travel dates, pick-up and drop-off points and any extras like a child seat. Scoring a vehicle that matches your needs and budget is a breeze with Expedia. Take a glimpse at our tempting deals from a variety of car rental companies, and then buckle up and explore Grand Lake O the Cherokees and beyond from behind the wheel.