Find all hotels by Independent in Santee, SC from CNY507
Compare rooms and suites by Independent in Santee with rates, reviews, and availability. Most hotels are fully refundable.
Independent Santee Hotel Guide
Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Santee, South Carolina. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Santee hotels guarantees an unparalleled level of comfort and quality.
You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Santee Independent locations may even offer extra little benefits and discounts for frequent travelers.
Recent reviews of Santee hotelsExpedia 亿客行 verified reviews
5/5 Excellent
"The staff was friendly, room clean and breakfast hot. "
A verified traveler stayed at Fairfield Inn & Suites by Marriott Santee
Posted 11 hours ago
Santee Hotels by Brand
Hotels near popular Santee Attractions
- Hotels near Santee State Park
- Hotels near Santee Cooper Country Club
- Hotels near Santee Outlets
- Hotels near Santee National Golf Club
- Hotels near Congaree National Park
- Hotels near Lake Marion
- Hotels near South Carolina State University
- Hotels near Santee National Wildlife Refuge
- Hotels near Wyboo Golf Club
- Hotels near Edisto Memorial Gardens
More Hotel Options in Santee
- Beach Hotels (1)
- Business Hotels (11)
- Cheap Hotels (7)
- Family Hotels (10)
- Fishing Resorts & Hotels (2)
- Golf Hotels (5)
- Hotel with a Concierge (1)
- Hotels & Resorts for Couples (3)
- Hotels on the Lake (4)
- Hotels with Air Conditioning (10)
- Hotels with Bars (6)
- Hotels with Connecting Rooms (5)
- Hotels with Free Breakfast (10)
- Hotels with Free Parking (11)
- Hotels with Free Wifi (11)
- Hotels with Hot Tubs (3)
- Hotels with Laundry Facilities (6)
- Hotels with Restaurants (11)
- Hotels with Room Service (2)
- Hotels with Suites (1)
- Hotels with a Gym (6)
- Hotels with a Pool (10)
- Hotels with an Indoor Pool (1)
- Hotels with an Outdoor Pool (10)
- Hotels with smoking rooms (1)
- Luxury Hotels (5)
- Non-Smoking Hotels (1)
- Pet-friendly Hotels (10)
- Resorts & Hotels with Spas (2)
More Accommodation Types in Santee
- Condo Rentals (16,454)
- Vacation Homes (14,528)
- Apartments (3,942)
- Villas (3,285)
- Resorts (1,024)
- Cottages (1,005)
- Aparthotels (195)
- Cabin Rentals (181)
- Motels (158)
- B&B (84)
- Guest Houses (68)
- Farmstay (39)
- RV Parks (35)
- Lodges (14)
- Condo Resorts (13)
- Chalets (7)
- Houseboats (7)
- Inns (4)
- Castles (3)
- Country Houses (1)
- Hostels (1)
- Residences (1)
Explore more hotels
- Two Palms Lakehouse in Santee Just minutes from I95
- Super 8 by Wyndham Santee
- Waterfront 3 Bedroom / 3 Bath Condo w/ Boat Slip Available
- Executive 2 BR/2 BA Lakefront Corner Suite Condo
- Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
- Rodeway Inn Santee I-95
- Wyndham Vacation Resorts Lake Marion
- Days Inn by Wyndham St George
- SureStay Hotel by Best Western Manning
- Tru by Hilton Orangeburg
- Country Inn & Suites by Radisson, Orangeburg, SC
- Fairfield Inn by Marriott Orangeburg
- SpringHill Suites by Marriott Orangeburg
- Travelodge by Wyndham Orangeburg
- Holiday Inn Express & Suites Orangeburg
- Hampton Inn Manning
- Baymont by Wyndham Manning
- Red Roof Inn St George, SC
- Hampton Inn & Suites Orangeburg
- Baymont by Wyndham Orangeburg North
Expedia's Latest Trends
Hotels
Charleston Oceanfront HotelsHotel Rooms in Mount PleasantMyrtle Beach Beach HotelsHotel Rooms in Myrtle BeachMyrtle Beach All-inclusive ResortsHotel Rooms in North Myrtle BeachHotel Rooms in GreenvilleMyrtle Beach Oceanfront HotelsHotel Rooms in Hilton Head IslandHilton Head Island Oceanfront HotelsHotel Rooms in ColumbiaHotel Rooms in FlorenceMyrtle Beach Cheap HotelsNorth Myrtle Beach Oceanfront HotelsHotel Rooms in CharlestonMyrtle Beach Pet-friendly Hotels
Cars
Cruises
Activities