Photo by Linda Cronan

Find hotels in Medical Center District, San Antonio from CNY401

Filter by

Popular filters
Popular filters
Price per night
Guest rating
Guest rating
Property class
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility
Traveler experience
Traveler experience

Discover 4,133 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Exterior
Hotel Contessa
4.0 star property
8.8 out of 10, Excellent, (2726)
"Everything was great! The valley guys were so helpful and polite, as well as the receptionist guy! I wish the restroom and carpet in the room felt cleaner."
The price is $174
$221 total
includes taxes & fees
4 Jun - 5 Jun
Hotel Contessa
Terrace/patio
Omni La Mansion del Rio
4.0 star property
9.2 out of 10, Wonderful, (2143)
"Front desk immensely helpful. Presidential suite above and beyond expectation. "
The price is $188
$226 total
includes taxes & fees
16 Jun - 17 Jun
Omni La Mansion del Rio
Miscellaneous
Grand Hyatt San Antonio River Walk
4.0 star property
8.8 out of 10, Excellent, (1078)
"Great place to stay!! Clean and convenient. "
The price is $194
$232 total
includes taxes & fees
31 May - 1 Jun
Grand Hyatt San Antonio River Walk
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Exterior
Drury Plaza Hotel San Antonio Riverwalk
3.0 star property
9.4 out of 10, Exceptional, (2581)
"The property has a very close proximity to the river walk. Close to the cathedral and most of the restaurants. I would come back for sure. Breakfast was lack luster."
The price is $118
$139 total
includes taxes & fees
9 Jun - 10 Jun
Drury Plaza Hotel San Antonio Riverwalk
Pool
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3.0 star property
8.4 out of 10, Very Good, (1322)
"I stayed for 2 nights. Valet parking was great and made it very easy. Staff was also very friendly. The hotel is older so you do have an older smell to the hall ways and the rooms. The room was nice and big. The water pressure was not very good in the shower or the sink. Breakfast was good and coffee was made earlier than the breakfast which is a plus for early risers. The only real complaint I would have and this was not their fault but there was a party going on in the building next door so...
The price is $104
$122 total
includes taxes & fees
9 Jun - 10 Jun
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Outdoor pool, sun loungers
Hampton Inn San Antonio-Downtown (River Walk)
2.5 star property
8.2 out of 10, Very Good, (2606)
"convenient to the convention center"
The price is $93
$110 total
includes taxes & fees
5 Jun - 6 Jun
Hampton Inn San Antonio-Downtown (River Walk)
Private pool
La Cantera Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1063)
"Loved this hotel so much. Amazing staff that were SO friendly from beginning to end. Super clean room and the housekeeper left us a sweet note. Beautiful property. Pools are 10/10. We will definitely be staying here again. "
The price is $399
$513 total
includes taxes & fees
18 Jun - 19 Jun
La Cantera Resort & Spa
Front of property
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 star property
8.6 out of 10, Excellent, (3024)
"Excellent "
The price is $89
$105 total
includes taxes & fees
29 May - 30 May
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Terrace/patio
Canopy by Hilton San Antonio Riverwalk
4.0 star property
9.4 out of 10, Exceptional, (1300)
"Great place.. location is perfect "
The price is $191
$230 total
includes taxes & fees
7 Jun - 8 Jun
Canopy by Hilton San Antonio Riverwalk
Exterior
Hilton Palacio Del Rio
4.0 star property
8.8 out of 10, Excellent, (1567)
"Close to everything "
The price is $177
$209 total
includes taxes & fees
9 Jun - 10 Jun
Hilton Palacio Del Rio
Lobby
Tru By Hilton San Antonio Downtown Riverwalk
2.5 star property
7.8 out of 10, Good, (1000)
"Restaurants and sightseeing were walking distance. "
The price is $93
$108 total
includes taxes & fees
5 Jun - 6 Jun
Tru By Hilton San Antonio Downtown Riverwalk
Meeting facility
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
3.0 star property
8.4 out of 10, Very Good, (1487)
"Awesome "
The price is $125
$148 total
includes taxes & fees
2 Jun - 3 Jun
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
Terrace/patio
AC Hotel by Marriott San Antonio Riverwalk
4.0 star property
8.4 out of 10, Very Good, (253)
"Great property, spacious rooms and friendly staff. "
The price is $122
$144 total
includes taxes & fees
23 Jun - 24 Jun
AC Hotel by Marriott San Antonio Riverwalk
Exterior
Home2 Suites by Hilton San Antonio Downtown - Riverwalk, TX
3.0 star property
8.0 out of 10, Very Good, (1000)
"Lots of homelessness but once in hotel felt safe due.to sacurity measures"
The price is $127
$150 total
includes taxes & fees
7 Jun - 8 Jun
Home2 Suites by Hilton San Antonio Downtown - Riverwalk, TX
3 outdoor pools, cabanas (surcharge), sun loungers
Hyatt Regency Hill Country Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1001)
"Great"
The price is $306
$411 total
includes taxes & fees
4 Jun - 5 Jun
Hyatt Regency Hill Country Resort & Spa
Lobby
Clarion Pointe near Medical Center
2.5 star property
7.2 out of 10, Good, (1188)
"Nice hotel, free breakfast, clean rooms, no weird people heard or seen around the location. Hotel staff where helpful and courteous."
The price is $55
$65 total
includes taxes & fees
5 Jun - 6 Jun
Clarion Pointe near Medical Center
Exterior
O´Brien Historic Hotel
3.5 star property
7.8 out of 10, Good, (1001)
"Condition, cleanliness and service was excellent."
The price is $116
$136 total
includes taxes & fees
5 Jun - 6 Jun
O´Brien Historic Hotel
Exterior
San Antonio Marriott Rivercenter on the River Walk
4.0 star property
8.8 out of 10, Excellent, (1001)
"Beautiful room, beautiful locstion"
The price is $194
$256 total
includes taxes & fees
29 May - 30 May
San Antonio Marriott Rivercenter on the River Walk
Restaurant
Element San Antonio Riverwalk
4.0 star property
8.6 out of 10, Excellent, (257)
"Great service "
The price is $118
$140 total
includes taxes & fees
30 May - 31 May
Element San Antonio Riverwalk
Exterior
Sonesta ES Suites San Antonio Northwest - Medical Center
3.0 star property
8.2 out of 10, Very Good, (1001)
"I really appreciate the warm, welcoming environment of Sonesta suites. I like the decor. It feels homey. I loved our room with the extra bedroom for our daughter. Felt like an apartment more than a hotel room. The beds and pillows were super comfy. Nice courtyard and pool area. Special bonus, a mama cat and kittens visited us when we were having breakfast on the patio. Breakfast was adequate, I noticed a lack of fresh fruit and no half-and-half for the coffee. I liked that there was a...
The price is $96
$113 total
includes taxes & fees
4 Jun - 5 Jun
Sonesta ES Suites San Antonio Northwest - Medical Center
Don't see what you're looking for?
See all available properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Medical Center District

Hotels in top San Antonio neighborhoods Learn more about Medical Center District
Downtown - Riverwalk which includes heritage architecture, boating and a river or creek

Downtown San Antonio

4 out of top 10 points of interest in this area
4/5(9,525 area reviews)

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

Find hotels in Downtown San Antonio

Medical Center District Travel Info

Number of reviews
25,377
Location
San Antonio, United States of America
Similar neighborhoods
Downtown San Antonio, North Central and Uptown
Accommodation
4,133 hotels
Known landmarks
San Antonio Aquarium, University of Texas Health and Science Center at San Antonio and Oak Hills Country Club
Hotels with nearby historical attractions
?SA STUDIO? Private Entry , Medical Center Condo for Medical Students, Professionals and Small Families. and Spacious Family Home Near San Antonio Hotspots!
Lowest price
CNY401
Highest price
CNY2,311

Frequently asked questions

What is Medical Center District like?

Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.

How many hotels will I be able to find in Medical Center District?

Expedia has 121 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.

Where can I learn more about changing or cancelling my trip to Medical Center District?

For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.

What can I see and do in this San Antonio neighborhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.

Recent reviews of Medical Center District hotels

JW Marriott San Antonio Hill Country Resort & Spa

JW Marriott San Antonio Hill Country Resort & Spa

5/5 Excellent
"My only complaint is that the restaurants are freezing cold from over air conditioning."
A verified traveler from Houston stayed at JW Marriott San Antonio Hill Country Resort & Spa
Posted 16 hours ago
JW Marriott San Antonio Hill Country Resort & Spa